Endocrine Abstracts

In the present study, we investigated neural alterations in newly diagnosed patients with mild hypothyroidism due to Hashimoto’s thyroiditis alongside mood and cognition as well as changes with treatment initiation. Animal studies and first studies of human brain metabolism using radioactive tracers suggest neural involvement in affective and cognitive symptoms of hypothyroidism. Here, we introduce non-invasive magnetic resonance imaging (MRI) techniques that allow the an...

Objective: The soluble leptin receptor (sOb-R) is generated by ectodomain shedding of the membrane-associated Ob-R and may modulate leptin action in metabolic dysregulations. The objective of our study was to investigate whether or not sOb-R generation may be induced by indicators of energy availability or metabolic regulators in a cell model.Material and methods: The four human Ob-R isoforms were cloned, characterized by binding experiments with 125-iod...

Poor agreement between different analytical methods measuring aldosterone concentrations impedes applicability of uniform cut-offs in the diagnostic work-up of primary aldosteronism (PA). We compared 4 analytical methods (2 immunoassays and 2 LC-MS/MS) in plasma samples before and after saline infusion test (SIT). 80 hypertensive patients underwent the standardized diagnostic work-up within the German Conn’s registry. Patients (PA n=39/non-PA n=41) were ...